High Purity Sex Enhancer Vardenafil Male Enhancement Powder Products CAS 224785-91-5

Vardenafil is a PDE5 inhibitor used for treating erectile dysfunction. Vardenafil's indications and contra-indications are the same as with other PDE5 inhibitors. The difference between the vardenafil molecule and is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both and vardenafil.

Vardenafil's relatively short effective time is comparable to but somewhat longer than sildenafil's.Vardenafil is a centrally-acting phosphodiesterase 5 inhibitor that is clinically used to treat erectile dysfunction. Vardenafil also exhibits antioxidative and antihypertensive activities and shows some potential for synergistic chemotherapeutic ability through its modulation of cGMP-

NO signaling. This compound increases expression of NO and eNOS as well as activity of superoxide dismutase, decreasing oxidative stress, pulmonary vascular resistance, and right ventricular hypertrophy and increasing cardiac output in animal models of pulmonary arterial hypertension. Vardenafil decreases proteinuria and glomerular damage in animal models of diabetic nephropathy-induced cGMP pathway dysfunction. In cellular models, vardenafil decreases secretion of IL-8 and expression of oxidative LDLR, suggesting potential benefit in the treatment of benign prostatic hyperplasia/low urinary tract syndrome.